Health Economics &
Outcomes Research
Overview
Health technology assessment (HTA) agencies and payers worldwide increasingly demand evidence of economic value for approval and market access of novel drugs, devices, and diagnostics. Avalon researchers and consultants have extensive knowledge and experience in the field of health economics and outcomes research (HEOR). These services include a wide variety of offerings across the product development continuum in pharmaceuticals, biotechnology, devices, and diagnostics. In the early stages of development, we provide insights and analysis on potential market size and the design of rigorous economic evaluations, such as clinical studies and cost-effectiveness analysis. In later stages of development, we can offer more in-depth analyses to support expanded market access. We are uniquely skilled in what we call “HEOR Analytics,” which includes novel statistical analyses of HEOR data, such as trial data or quality of life data, and novel applications of those analyses to statistical and economic models.
Types Of Engagements
- Building cost offset and cost impact models for novel diagnostics
- Cost-effectiveness analyses and budget impact analyses in oncology
- Cost offset and cost impact models in treatment for kidney disease
- Economic evaluation of liquid biopsies
- Budget impact model of a novel drug
- Global model adaptations
- Survival analysis in outcomes research
- Cost effectiveness analysis of combination drugs
- Developing value propositions for novel medical devices
- Mendelian randomization to assess causative factors in obesity
- Conceptual models of disease progression & treatment of chronic obstructive pulmonary disease
- Novel analysis of real-world data (RWD) to support HTA submissions
- Estimation of market size for medical devices, diagnostics, & pharmaceuticals
- Systematic & comprehensive summaries of literature & evidence
- Publications in peer-reviewed journals
Key Staff
- John Schneider, PhD
- Andrew Briggs, DPhil, MSc
- Robert Ohsfeldt, PhD
- Jacie Cooper, MS
- Anthony LoSasso, PhD
Related Markets & Industries
- Insurance & Third-Party Payers
- Medical Services
- Hospitals & Health Systems
- Pharmaceuticals & Biotechnology
- Medical Devices & Diagnostics
- Private Equity & Venture Capital
- Consumer Products
- Public Health
- Government
Related Publications
- Cost-effectiveness analysis of LungLB for the clinical management of patients with indeterminate pulmonary nodules. 2023
- Challenges for decision-makers when assessing within-class comparative effectiveness: the case of anticoagulation therapy for atrial fibrillation. 2022
- Cost impact analysis of novel host-response diagnostic for patients with community-acquired pneumonia in the emergency department. 2022
- Beyond Ten-Year Risk: A Cost-Effectiveness Analysis of Statins for the Primary Prevention of Cardiovascular Disease. 2022
- Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations. 2022
- Developing a Framework for the Health Technology Assessment of Histology-independent Precision Oncology Therapies. 2021
- Reimbursement for genetic variant reinterpretation: five questions payers should ask. 2021
- Count the cost of disability caused by COVID-19. 2021
- Estimating (quality-adjusted) life-year losses associated with deaths: With application to COVID-19. 2021
- Mendelian randomization: estimation of inpatient hospital costs attributable to obesity. 2021
- An Attribution of Value Framework for Combination Therapies: Report by the Value Attribution Working Group. 2021
- Cost-impact analysis of baroreflex activation therapy in chronic heart failure patients in the United States. 2021
- Genetic Variant Reinterpretation: Economic and Population Health Management Challenges. 2021
- A Cost-Offset Analysis of the Roxadustat Incident Dialysis-Dependent Global Phase 3 Program: A US Healthcare Perspective. 2021
- A Cost-Offset Analysis of the Roxadustat Incident Dialysis-Dependent Global Phase 3 Program: A Canadian Healthcare Perspective. 2021
- Cost Impact Model of a Novel Multi-mRNA Host Response Assay for Diagnosis and Risk Assessment of Acute Respiratory Tract Infections and Sepsis in the Emergency Department. 2020
- Covariate-adjusted Analysis of the Phase 3 REFLECT Study of Lenvatinib Versus Sorafenib in the Treatment of Unresectable Hepatocellular Carcinoma. 2020
- Application of a simple point-of-care test to reduce UK healthcare costs and adverse events in outpatient acute respiratory infections. 2020
- Real-world evidence on clinical outcomes in immune thrombocytopenia treated with thrombopoietin receptor agonists. 2020
- Economic evaluation of cardiac magnetic resonance with Fast-SENC in the diagnosis and management of early heart failure. 2019
- Cost-impact of cardiac magnetic resonance imaging with Fast-SENC compared to SPECT in the diagnosis of coronary artery disease in the U.S. 2019
- Economic evaluation of passive monitoring technology for seniors. 2019
- 3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer: 3-year follow-up of the SCOT non-inferiority RCT. 2019
- Comparison of health state utility estimates from instrument-based and vignette-based methods: a case study in kidney disease. 2019
- A quality of life mapping function developed from a grass pollen sublingual immunotherapy trial to a tree pollen sublingual immunotherapy trial. 2019
- Statistical Modeling of Disease Progression for Chronic Obstructive Pulmonary Disease Using Data from the ECLIPSE Study 2017
- Cost-effectiveness Analysis in R Using a Multi-state Modeling Survival Analysis Framework: A Tutorial. 2017
- Determination of the most appropriate method for extrapolating overall survival data from a placebo-controlled clinical trial of lenvatinib for progressive, radioiodine-refractory differentiated thyroid cancer 2016
- A cardiovascular disease policy model that predicts life expectancy taking into account socioeconomic deprivation. 2015
- Hospital Expenditure at the End-of-Life: What Are the Impacts of Health Status and Health Risks? 2015
- Projecting long-term graft and patient survival after transplantation. 2014
- Methods for Specifying the Target Difference in a Randomised Controlled Trial: The Difference ELicitation in TriAls (DELTA) Systematic Review. 2014
- Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review. 2014
- Population ageing and healthcare expenditure projections: new evidence from a time to death approach. 2013
Related Issue Briefs
- Economic Evaluation and Market Access for Medical Devices in the U.S.: Implications of a U.S. Health Technology Assessment Agency (Issue Brief No. 53)
- Moving Beyond ‘Lives-Saved’ From COVID-19 (Issue Brief No. 50)
- Economic Cycles and Product Development in Life Sciences (Issue Brief No. 49)
- Applications of HEOR Analytics: Covariate-Adjusted Analysis of Phase 3 Clinical Trial Data of Lenvatinib versus Sorafenib in Hepatocellular Carcinoma (Issue Brief No. 47)
- How Important is ICER Preparation and Review for U.S. Market Access? (Issue Brief No. 43)
- Using Payer Research to Assess Medical Device Market Access (Issue Brief No. 42)
- Smoke, Mirrors, and Wild Geese: What Should Be the Future Directions of HEOR in the 2020s? (Issue Brief No. 40)
- Avalon Health Economics at the 20th Annual European Conference of ISPOR (Issue Brief No. 39)
- The Value of Biopharmaceutical Innovation in the U.S. (Issue Brief No. 38)
- The Evolving Landscape of U.S. Payer Coverage Decisions: The Role of Health Economics and Outcomes Research (Issue Brief No. 37)
- Will Changes in the Affordable Care Act Result in Organizational Changes in U.S. Medical Care? Implications for Economic Evaluation of Drugs & Devices (Issue Brief No. 36)
- Medical Device Economics and the Health System Purchaser in the Era of Novel Payment Mechanisms (Issue Brief No. 35)
- Value-Based Payment for Oncology Services (Issue Brief No. 34)
- Why Medical Device Companies Need to Develop Economic Evidence in the U.S. (Issue Brief No. 33)
- Reference Pricing for in vivo and in vitro Diagnostic Tests (Issue Brief No. 32)
- Purchasing Medical Innovation: The Implications for the Medical Device Industry (Issue Brief No. 31)
- Controlling the Costs of Clinical Laboratory Testing in Medical Practice (Issue Brief No. 29)
- The New Era of Cost Control in Healthcare: What Should you look for in a Health Economics and Outcomes Research Consultant? (Issue Brief No. 27)
- Paying for Specialty Pharmaceuticals: The Case of Injectable Oncology Drugs (Issue Brief No. 26)
- Integration of Novel Diagnostics into Clinical Practice (Issue Brief No. 25)
- The State of the Union and Innovation in Molecular Diagnostics (Issue Brief No. 24)
- The Evolving Role of the New Generation of Molecular Diagnostics in U.S. Health Markets: Development, Clinical Integration, and Evaluation (Issue Brief No. 15)
- The Economics of Ovarian Cancer Diagnosis (Issue Brief No. 12)
- Value-Based Purchasing for Hospital Services in the U.S. (Issue Brief No. 11)
- Reshaping the Clinical Laboratory in the Era of Patient-Centered Outcomes, Accountable Care Organizations, and Pharmacogenomics (Issue Brief No. 10)
- Training the Health Economics and Outcomes Research Workforce of the Future: Opportunities for Program Development in Colleges and Universities (Issue Brief No. 4)