The Avalon team employed Mendelian randomization to help Novartis understand the proportion of obesity costs that might be explained by genetic causes.
Abstract
Background
Mendelian Randomization is a type of instrumental variable (IV) analysis that uses inherited genetic variants as instruments to estimate causal effects attributable to genetic factors. This study aims to estimate the impact of obesity on annual inpatient healthcare costs in the UK using linked data from the UK Biobank and Hospital Episode Statistics (HES).